Application of Multicomponent Reactions for the Synthesis of Diverse Heterocyclic Scaffolds

With regard to the development of sustainable chemical methods, new reactions should proceed with cheap and easily available substrates, at best in a common apparatus giving a quantitative yield at a fast rate and 100% atom economy. Clearly, for multi-step synthetic procedures the number of reaction and purification steps are among the most important criteria for the efficiency and practicability of the process and should be as low as possible. Concerning to these aspects, multicomponent and domino reactions offer significant advantages. In the drug discovery process, MCR offers many advantages over traditional approaches. The advantages like minimum biproducts, ease of purification of product, less reaction time, construction of complex scaffolds in an easy manner and the atom economy principal are the specialties which make multicomponent reactions an attractive choice for synthetic as well as medicinal chemists. The adoption of multicomponent approaches gradually become more common in natural products synthesis, medicinal chemistry, synthesis of dyes, bioconjugation and polymer synthesis. Hence the development of multicomponent reaction is one of the prime necessities among the scientific community today. Present book is written in keeping the importance of multicomponent reactions for synthesis of various heterocycles and tried to give a comprehensive view regarding the synthesis of heterocycles. Book is divided in several chapters consisting of 3 membered, 4 membered, 5 membered, 6 membered and 7 membered heterocycles for ease of understanding of readers. Detailed synthetic pathways are designed and presented in schematic manner to make it attractive and handier for researchers. Text included in the book is believed to be beneficial and informative and will be milestone for synthetic chemists in field of heterocycle synthesis.